Smoking gun

Gravity’s Smoking Gun?

We present a new constraint on the biased galaxy formation picture. Gravitational instability theory predicts that the two-point mass density correlation function, ξ(r), has an inflection point at the separation r = ro, corresponding to the boundary between the linear and nonlinear regime of clustering, ξ ≃ 1. We show how this feature can be used to constrain the biasing parameter, b ≡ ξg(r)/ξ(...

The smoking gun of eugenics

Editorial: Aluminum – Alzheimer's Smoking Gun?

It is becoming apparent that with an aging population comes an increase in the incidence of mental impairment. In death certificates of people over 75 years of age, the number listed as having dementia has increased by a factor of 20 in the last 15 years (Forbes, Lessard, & Gentleman, 1995, appearing in the present issue). Most of this increase is probably the result of heightened diagnostic se...

Smoking Gun or Red Herring

In this issue of Circulation Research, Zhang et al1 provide direct and clear evidence that phosphorylation of S2808 in the cardiac ryanodine receptors (RyR2) has no impact on either normal cardiac function, sympathetic stimulation of the heart, or progression of heart failure (HF) after myocardial infarction (MI). They used mice in which the S2808 site was rendered nonphosphorylatable in S2808A...

Cigarettes: a smoking gun in cancer chemoprevention.

Affi liations of authors: Yale University School of Medicine and Yale Cancer Center, Department of Epidemiology and Public Health, New Haven, CT (STM); Departments of Clinical Cancer Prevention and Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX (SML). Correspondence to: Scott M. Lippman, MD, Department of Clinical Cancer Prevention — U...